Highlights
• Biomimetic synthesized mesoporous silica nanoparticles (B-MSNs) were used as carrier.
• Famotidine (FMT) loaded B-MSN exhibited a little controlled release effect.
• Control-release microcapsule of FMT loaded B-MSN controlled FMT release for 24 h.
• Stomach adhesion was enhanced by control-release microcapsule of FMT loaded B-MSN