02. March 2015

    Investigation of Drug–Excipient Interactions in Lapatinib Amorphous Solid Dispersions Using Solid-State NMR Spectroscopy

    Mol. Pharmaceutics, 2015, 12 (3), pp 857–866

    DOI: 10.1021/mp500692a

    Publication Date (Web): January 13, 2015

    Copyright © 2015 American Chemical Society

    *E-mail: lubach.joseph@gene.com

    This study investigated the presence of specific drug–excipient interactions in amorphous solid dispersions of lapatinib (LB) and four commonly used pharmaceutical polymers, including Soluplus, polyvinylpyrrolidone vinyl acetate (PVPVA), hydroxypropylmethylcellulose acetate succinate (HPMCAS), and hydroxypropylmethylcellulose phthalate (HPMCP)…

    http://pubs.acs.org/doi/abs/10.1021/mp500692a?mi=2gvdg1k&af=R&field1=AllField&targetTab=std&text1=excipient&target=default&sortBy=Earliest

    Tags: Solid, interaction, dispersion, Amorphous, drug-excipient, lapatinib, NMR, mar2015