Orally disintegrating films (ODFs) can transport natural active compounds such as hydrolyzed collagen (HC) and ethanol extract of propolis (EEP). This paper aimed to investigate the effect of lecithin on different gelatin and HC polymeric matrices with addition of EEP. ODFs were prepared by casting and were characterized (color parameters, water content, mechanical properties, microstructure, disintegration time (DT), infrared spectroscopy (FTIR), contact angle (CA), swelling degree and total phenolic content (CTP)). The mechanical properties were influenced by HC.