We aimed to develop a suitable micropellet delivery system for Lansoprazole, a highly potent proton pump inhibitor and acid-unstable physiologically active anti-secretory compound. Although clinically manifested to be highly effective for treating acid reux-related diseases, poor water solubility and short gastric retention time, typically does not provide extended period of relief. Materials and method: Micropellets of the drug was prepared using ionotropic gelation technique, where gelation of anionic sodium alginate, the primary polymer, was achieved with oppositely charged counter ion to form microparticles and subjected to several characterization studies.
Micropellets: A promising strategy for controlled release of lansoprazole
Vinod Dhote , Dinesh Kumar Mishra , Pradyumna Kumar Mishra , Kanika Dhote 1* 2 3 4
1 Truba Institute of Pharmacy, Bhopal (M.P.), India.
2 Department of Pharmaceutics, College of Pharmacy, IPS Academy, Indore (M.P.) India.
3 School of Biological Sciences, Dr. H. S. Gour Central University, Sagar, India
4 Ravishankar College of Pharmacy, Bhopal (M.P)
1 Truba Institute of Pharmacy, Bhopal (M.P.), India.
2 Department of Pharmaceutics, College of Pharmacy, IPS Academy, Indore (M.P.) India.
3 School of Biological Sciences, Dr. H. S. Gour Central University, Sagar, India
4 Ravishankar College of Pharmacy, Bhopal (M.P)