“Mini-tablets” (MTs) are tablets of diameter ≤ 3 mm and have been widely studied and developed. However, reports comparing MTs with other tablet formulations are few. We wished to evaluate the ease of taking a MT quantitatively in comparison with an orally disintegrating mini-tablet (ODMT), conventional tablet (CT) and conventional orally disintegrating tablet (ODT). Four types of tablets were prepared. We prepared tablets of two diameters (3 mm for MTs and ODMTs vs. 8 mm for CTs and ODTs) and two formulations (MTs and CTs vs. ODMTs and ODTs). Our randomized crossover trial in 18 healthy volunteers (8 men and 10 women; mean age, 22.5 years) indicated that the visual analogue scale (VAS) score for the ease and amount of water required for intake of MTs was significantly lower than those of CTs.