Formulation and development of pH-independent/dependent sustained release matrix tablets of ondansetron HCl by a continuous twin-screw melt granulation process.

The objective of the present study was to develop pH-independent/dependent sustained release (SR) tablets of ondansetron HCl dihydrate (OND), a selective 5-HT₃ receptor antagonist that is used for prevention of nausea and vomiting caused by chemotherapy, radiotherapy and postoperative Treatment..

http://www.ncbi.nlm.nih.gov/pubmed/25863118