Binder addition methods alter granule shape that predominantly governs granule flow.
Binder-diluent affinity dominates other factors to influence the granule growth.
PVP as a binder produce more round and friable granules compared to the HPMC.
High polydispersity index of polymer-binder facilitates blend segregation potential.
Mannitol tablets achieve higher hardness, while lactose tablets disintegrate faster.