Electrospinning of Eudragit® FS 100 was investigated for the first time.
• Novel AC electrospinning produced excellent quality nano fibers at high throughput.
• Melt rheology of Eudragit® FS 100 was thoroughly explored.
• Eudragit® FS-based solid dispersions provided excellent control on release of poorly soluble spironolactone as pH varied.