The permeability of a powder bed reflects its particle size distribution, shape, packing, porosity, cohesivity, and tensile strength in a manner relevant to powder fluidization. The relationship between the permeability and the performance of carrier-based dry powder inhalation (DPI) mixtures has, however, aroused controversy. The current study sought to gain new insights into the relationship and to explore its potential applications. We studied eight lactose materials as DPI carriers. The...
The porous PLGA particles for pulmonary delivery were prepared.
The shape factor should not be determined only by the outline of particles.
The particles had specific internal structures with unusual aerodynamic performances.