Abstract The objective of this study was to evaluate the combination of pH-dependent and time-dependent polymers on drug release in order to optimize coating for colonic delivery. Response surface methodology (RSM) based on central composite design (CCD) was employed for formulation optimization. Theophylline was used as model drug and Eudragit® FS 30D and hydroxypropyl methylcellulose (HPMC) were used as pH-dependent and time-dependent polymer, respectively. Dissolution test was carried out...
Abstract: The objective of this study was to design and evaluate Sitagliptin Phosphate immediate release (IR) 50 mg tablet using Response Surface Methodology for the managemant of Type-II diabetes mellitus. Response surface methodology (RSM) computations for this optimization study were performed employing Minitab 16. Different formulations of immediate release were prepared by applying 2 factor 2 level Central Composite Design (CCD) using Minitab 16 which gave 13 formulation for each layer....
Galantamine hydrobromide (GH) is an effective drug for Alzheimer's disease. It is currently delivered via the oral route, and this might cause nausea, vomiting, and gastrointestinal disturbance. In the present work, GH was formulated in a gel-type drug reservoir and then optimized by using response surface methodology (RSM) based on central composite design. More