The last fifty years, ophthalmic drug delivery research has made much progress,
challenging scientists about the advantages and limitations of this drug delivery approach. Topical eye
drops are the most commonly used formulation in ocular drug delivery. Despite the good tolerance
for patients, this topical administration is only focus on the anterior ocular diseases and had a high
precorneal loss of drugs due to the tears production and ocular barriers. Antibiotics are popularly
used in solution