The purpose of the research described herein was to develop a kinetic model for quantifying the effects of conditional and compositional variations on non-covalent polymorphic and covalent chemical transformations of gabapentin.
This study focuses on understanding the physicochemical principles for the preparation of high drug-loaded microgranules with a desired size distribution and mechanical properties. Mesalamine was selected as a model drug, and microgranulation was performed using an extruder and a conical screen mill.