28. September 2017
The wetting and dissolution of a BCS class II drug (Ibuprofen) is enhanced by solventless solid dispersion technique using co-milling. The co-milling is performed in a planetary ball mill using 1:1 wt. ratio of Ibuprofen (drug) and Microcrystalline cellulose, MCC (excipient).The improvement in wettability and dissolution after co-milling are compared with the raw ibuprofen, ball-milled ibuprofen without any excipient and v-blend mixture of ibuprofen with an excipient. The changes in crystal...
05. February 2016
The aim of this study was to enhance the dissolution and bioavailability of telmisartan (TLM), a poorly water soluble drug by comilling approach. Physical mixtures of TLM and poly(vinyl alcohol) (PVA) were comilled in a planetary micro mill in a dry condition by varying process parameters such as drug to polymer weight ratio, ball-to-powder weight ratio, and rotational speed. The comilled products that offered cumulative percentage dissolution of TLM above 75% in 30 min (CG 1 and CG2). These...