The development of self-nanoemulsifying drug delivery systems (SNEDDS) to enhance the oral bioavailability of lipophilic drugs, is usually based on traditional one-factor-at-a-time approaches.
Aim: The aim of this work is development and evaluation of chlorhexidine medicated chewing gums by different methods and to study the influence of different plasticizers and methods on physicochemical parameters and in vitro drug release profile. Materials and Methods: Chlorhexidine is an antibacterial agent used for management of tooth decay. The formulations are prepared with varying concentrations of plasticizers and synthetic gum base by different methods such as direct compression and...