An increase in the proportion of poorly aqueous soluble drugs that exhibit problems in oral bioavailability is one of the major problems in formulation development. Formulation of lipid-based nanocarriers, such as self-nanoemulsifying drug delivery systems (SNEDDS) and self-microemulsifying drug delivery systems (SMEDDS) have received a lot of attention in recent years as an approach for overcoming poor solubility and oral bioavailability of drugs. SNEDDS are isotropic mixtures of oil,...
The development of self-nanoemulsifying drug delivery systems (SNEDDS) to enhance the oral bioavailability of lipophilic drugs, is usually based on traditional one-factor-at-a-time approaches.
This study aims to develop a self-nanoemulsifying drug delivery system (SNEDDS) based on non-ionic surfactant mixtures to improve the oral bioavailability of efavirenz (EFZ) categorized as a class II according to the BCS, for HIV- therapy. The result of solubility studies of EFZ in various excipients utilized for construction of the pseudo ternary phase diagram containing surfactant mixtures. Surfactants in 1:1 combination are used with different co-surfactants in different ratio to delineate...
The present work focusses on the formulation development and evaluation of functional excipient (surfactant stabilizer), Vitamin E TPGS loaded self-nanoemulsifying drug delivery system (SNEDDS) for improving deliverability and safety profile of Cyclosporine A (CyA)…. Sanyog Jain, Sindhu Kambam, Kaushik Thanki and Amit K Jain RSC Adv., 2015, Accepted Manuscript DOI: 10.1039/C5RA04762E Received 18 Mar 2015, Accepted 20 May 2015 First published online 20 May 2015...
The objective of the present study was to prepare solid self-nanoemulsifying drug delivery system (S-SNEDDS) containing Capryol-90 as oil phase for the delivery of Embelin, a poorly water soluble herbal active ingredient... http://www.sciencedirect.com/science/article/pii/S1818087615000410