Novel medicated straws were developed based on drug-loaded
electrospun fibers prepared by direct current electrospinning
(DCES) and high-speed electrospinning (HSES) of scaled-up
productivity. Good quality micro- and nanofibers were
electrospun using both techniques despite the multiple times
higher throughput rate of HSES based on the scanning electron
microscopic imaging (SEM). Solid state analyses revealed that
the poorly soluble model drug carvedilol (CAR) was dispersed
in an amorphous form
The aim of this new work was to improve the dissolution rate of poorly water-soluble cilostazol (CLT) by adsorbing dissolved drug molecules onto the surface of undissolved carriers via reprecipitation and deposition process as the solvent (methylene chloride) was evaporated. The adsorption mixtures of CLT with Aerosil 300 and lactose monohydrate provided better drug dissolution rate as compared to mannitol.