Fused deposition modeling 3D printing (3DP) has a potential to change how we envision manufacturing in the pharmaceutical industry. A more common utilization for FDM is to build upon existing hot melt extrusion technology where the drug is dispersed in the polymer matrix. However, reliable manufacturing of drug-containing FDM filaments remains a challenge along with the limitation of active ingredients which can sustain the processing risks involved in the HME process. To circumvent this...
Mesalazine also known as mesalamine (5-aminosalicylic acid) is the amino deriva- tive of salicylic acid, this molecule possesses an amphoteric character due to the pres- ence of the carboxyl and amino groups. So; the value of the pH medium has a strong effect on its solubility and protonation.