04. September 2017

Abstract Excipients are an integral part of practically all medicines. Historically, excipients have been regarded as pharmacologically and chemically indifferent within the formulation. However, nowadays excipients along with active pharmaceutical ingredients are the subject of strict monitoring and quality control in pharmaceutical manufacture. According to the current rules of European Union’s Good Manufacturing Practice of Medicinal Products excipients should be subjected to a thorough...

29. January 2017

Poorly soluble and/or permeable molecules jeopardize the discovery and development of innovative medicines. Pharmaceutical co-crystals, formed by an active pharmaceutical substance (API) and a co-crystal former, can show enhanced dissolution and permeation values compared with those of the parent crystalline pure phases. It is currently assumed that co-crystallization with pharmaceutical excipients does not affect the pharmacological activity of an API or, indeed, might even improve physical...

10. August 2016

Abstract The objective of this study was to analyze differences in the subtle microstructure of three different grades of HMPC hard capsule shells using mechanical, spectroscopic, microscopic and tomographic approaches. Dynamic mechanical analysis (DMA), thermogravimetric analysis (TGA), vibrational spectroscopic, X-Ray scattering techniques as well as environmental scanning electron microscopy (ESEM) and optical coherence tomography (OCT) were used. Two HPMC capsules manufactured via chemical...

21. April 2016

The present study aimed to develop and optimize the wax based floating sustained-release dispersion pellets for a weakly acidic hydrophilic drug protocatechuic acid to achieve prolonged gastric residence time and improved bioavailability. This low-density drug delivery system consisted of octadecanol/microcrystalline cellulose mixture matrix pellet cores prepared by extrusion-spheronization technique, coated with drug/ethyl cellulose 100cp solid dispersion using single-step fluid-bed coating...

24. February 2016

Natural polymers and their derivatives have been widely used in pharmaceutical and food industries. The development of delivery systems using natural polymers such as gums offers distinct advantages, such as, biocompatibility, biodegradability, and cost effectiveness. Cashew gum (CG) is an exudate taken from Anacardium occidentale, which is a common tree in Braziĺs northeastern region. CG has rheological and mucoadhesive properties that can find many applications, among which the design of...

30. January 2016

This study was aimed at isolating, characterizing and evaluating the excipient functionalities of a polymer from watermelon seeds. After oil extraction, the marc was dispersed in water, agitated, filtered, the polymer harvested as the sediment in the filtrate and purified. The polymer was characterized; used as excipient in tablet formulation; and tablets' qualities were assessed using standard protocols. Physicochemical tests revealed polymer as non-polysaccharide, amorphous biomaterial with...

25. November 2015

22. October 2015

22. July 2015

Polypeptide from Catharsius molossus L. is an active ingredient in the treatment of benign prostatic hyperplasia. The residue after extraction is harmful to the environment and is also a waste of resources. Chitosan was extracted from Catharsius molossus L. residue with chemical methods and with an improved intermittent heating method. More