Any imbalance in body's pH or temperature may alter immune response and lead to conditions such as autoimmune disorders, infectious diseases, cancer and diabetes. Dual pH and thermo-responsive carriers have been striving forward as next generation therapeutic medicines as they can intelligently trigger drug release in a stimuli responsive manner with minimal toxicity, improved therapeutic efficacy and reduced exposure to normal cells. Besides polymeric nanoparticles and polymeric micelles,...
Combined therapy is a global strategy developed to prevent drug resistance in cancer and infectious diseases. In this field, there is a need of multifunctional drug delivery systems able to co-encapsulate small drug molecules, peptides, proteins, associated to targeting functions, nanoparticles.