To obtain a reproducible and specification conforming product quality it is mandatory to control the process parameters for granulation and layering or coating. One important parameter for the development of coating and granulation processes in high shear and fluid bed processes is the spraying system [1] e. g. the application of a feasible droplet size coming out of the respective spraying nozzle. Too large droplets could result in oversized granules or in pellets´ agglomeration, whereas too...
by Innopharmatechnology & Glatt @ PMEC India 2017 Learn about the latest Process Analytical Technology (PAT) technical and application developments for in-line PSD and Moisture measurement in fluid bed batch and continuous powder processes. More
The objective of this study was to prepare time-controlled release etodolac pellets to facilitate drug administration according to the body’s biological rhythm, optimize
the drug’s desired effects, and minimize adverse effects.
Fluid bed coating offers potential advantages as a formulation platform for amorphous solid dispersions (ASDs) of poorly soluble drugs, being a one-step manufacturing process which could reduce therisk of phase separation associated with multiple step manufacturing approaches. However, the impact of the physicochemical nature of carrier spheres on the properties and drug release from the ASDshas not been studied in detail. In this work, tartaric acid (TAP) and microcrystalline cellulose (CEL)...
The purpose of this work was to develop multi unit particulate formulation using fluid bed processor for the controlled release of Metoprolol succinate and to understand the impact of formulation parameters on the critical quality attributes using a quality-by-design approach.
The multiparticulate drug product concept covering micropellets, pellets, and mini-tablets is presented as a highly feasible approach to present convenient and patient friendly medication for the geriatric population. Improved swallowability and optimized administration regimen going along with defined drug dosage are achievable.
MARCH 6 - 9, 2016 - Long Island University, Brooklyn, NY LECTURES & LABORATORY EXERCISES WILL COVER Formulation Development • Modified Release Technologies Tablet Tooling Design • Tablet Scale Up Issues with HANDS-ON LEARNING where YOU OPERATE the equipment!
Compaction of multiple-unit pellet system (MUPS) tablets has been extensively studied in the past few decades but with marginal success. This study aims to investigate the formulation and process strategies for minimizing pellet coat damage caused by compaction and elucidate the mechanism of damage sustained during the preparation of MUPS tablets in a rotary tablet press. More