23. February 2017
Abstract Tablet compaction is an important unit operation in the pharmaceutical industry. Among the compaction parameters, dwell time is a key parameter that has been consistently been shown to impact the mechanical quality of tablets. Compacts experience a state of relatively constant strain during the dwell phase and this allows time dependent reactions such as viscoelastic flow to take place within the tablet microstructure. The importance of time dependent compact deformation during the...
07. January 2016
Compaction of multiple-unit pellet system (MUPS) tablets has been extensively studied in the past few decades but with marginal success. This study aims to investigate the formulation and process strategies for minimizing pellet coat damage caused by compaction and elucidate the mechanism of damage sustained during the preparation of MUPS tablets in a rotary tablet press. More