03. December 2017

The aims of this study are to prepare and characterize a microemulsion-based hydrogel containing celecoxib (CLX) for transdermal delivery. Pseudo-ternary phase diagrams containing 0.74% (w/w) CLX were constructed usingawater titration method. The mixture exhibiting the largest area of the microemulsionregion was selected. The effect of the ratio of oil to themixtureof surfactant and cosurfactant (O/Smix) on in vitro skin permeation was investigated. Attenuated total reflectance-Fourier...