Abstract Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt extrusion. Since ITZ possesses a water solubility of less than 1 ng/mL, the aim of this work was to enhance the aqueous solubility of ITZ, and thereby improve its bioavailability. The three formulations consisted of a simple SOL/ITZ amorphous solid dispersion (ASD), an optimized...
Highlights •Novel BC composites with improved mechanical integrity. •Sustained in vitro release of the antibiotic (levofloxacin) from the BC composites over an 8-week period. •Levofloxacin retained the antimicrobial activity against Staphylococcus aureus and Staphylococcus epidermidis over an 8-week in vitro release period. •Biocompatible BC composites. See more