Mucoadhesive formulations are well known for the delivery of drugs via the mucosal membrane of oral (sublingual, buccal and gingival), rectum, nose, eyes, and vagina. Among the various drug delivery approaches, the buccal mucosa delivery system offers several benefits like easy accessibility, patient compliance, a relatively large surface area of absorption for drug molecules, reduced gastric irritation and simple delivery devices. Moreover, the drugs penetrate the mucous membrane by simple diffusion and are carried in the blood, which is richly supplied with the salivary glands and their ducts, into the systemic circulation via the jugular vein. This noteworthy background supported delivery of different classes of drugs through buccal drug delivery systems. This book chapter discuss the research carried out for buccoadhesive dosage forms of the drugs such as antifungal, antiemetic, antibiotics, antihistamines, non-steroidal anti-inflammatory drugs, drugs used for lungs related disorders, drugs acting on cardiovascular system, central nervous systems including antidepressants, drugs for migraine, antiparkinson’s, antipsychotic, antiepileptic, neuromodulator, muscle relaxant, antidiabetic, anaesthetic drugs, antiviral, anticholinergic, anticonvulsant, anticancer, diuretics, antiseptic, statins, beta blockers and corticosteroids. Mucoadhesive drug delivery system thus proves to be an inevitable system for both immediate and sustained release of the drug. Further advances in buccal adhesive technology for effective local and systemic action also have the potential for reducing the dose and side effects.
Department of Pharmacy, School of Chemical & Biotechnology, SASTRA University, India
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