DEVELOPMENT OF MICROPARTICLES FOR SUSTAINED RELEASE OF PROTEINS BASED ON LIPID AND SILICA MATERIALS

Objectives of the thesis

Many protein drugs exhibit short half-lives in vivo and multiple dosing schemes and frequent injections are necessary to achieve therapeutic drug levels, which results in poor patience compliance. Due to the good biocompatibility of triglycerides and silica materials, the objective of this work was to develop protein loaded microparticles for sustained release application based on triglycerides and silica (TMEOS) carriers. It included two main parts, which were lipid coating of protein carrying beads in a fluid bed coater and silica particle fabrication via spray drying.