Excipient selection strongly influences lyophilization performance for biologic drugs
Lyophilization, or freeze drying, is a well-recognized method for obtaining stable biologic drug products that have short shelf-lives in solution form. Lyophilized products are easy to store and ship. Because freeze-drying is a low-temperature process, thermal degradation is minimized. Furthermore, the preparation of high concentration formulations is readily achievable using lyophilized material.
For Lyophilization, Excipients Really Do Matter
Jan 01, 2017 - By Cynthia A. Challenger - Biopharma International - Volume 30, Issue 1, pg 32–35