ABSTRACT
Co-processing is one of the ways to develop new excipients for the pharmaceutical industry. Co-processed excipients are a combination of established two or more excipients through physical mixing or co-process technology. Co-processed excipients has no change in chemical structure, it only changes physical properties of the final product. Co-processing technology could lead to formation of co-processed excipient with superior physical properties compared to simple physical mixtures of their components. In this study we will be manufacturing (HiCelTM SMCC) Silicified microcrystalline cellulose, which is a combination of two pharmaceutical excipients, one is colloidal silicon dioxide and second is (HiCelTM) Microcrystalline cellulose. (HiCelTMSMCC) Silicified Microcrystalline Cellulose is made by co-processed technology.HiCelTMSMCC90M grade of Silicified microcrystalline cellulose is used to manufacture the Paracetamol (PCM) tablet using direct compression technology. It is a good choice of excipients for direct compression formulation. The main aim of co-processing is to obtain product with a benefit related to the ratio of it functionality or costing.
Sigachi® Industries private limited, Dahej SEZ Gujarat, India.
*Corresponding author’s E-mail: monika@sigachi.com