The Solubility of Microcrystalline Cellulose in Sodium Hydroxide Solution Is Inconsistent with International Specifications

Abstract

Microcrystalline cellulose (MCC) is used globally as an inactive ingredient in food and nutraceutical products and is commonly used as a food additive. To confirm the conformity of MCC to the solubility requirements stipulated in international specifications, the solubilities of commercially available MCC products were tested in sodium hydroxide (NaOH) solution. All of the samples were insoluble in NaOH solution, which is inconsistent with the descriptions provided in international specifications. We also prepared celluloses with different degree of polymerization (DP) values by acid hydrolysis. Celluloses with lower DP were prepared using a three-step process, and their solubilities were tested in NaOH solution. These celluloses were found to be insoluble, which is inconsistent with the descriptions provided in international specifications. The present study suggests that the descriptions of the solubility of the celluloses in NaOH solution found in the current international specifications should be revised.

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The Solubility of Microcrystalline Cellulose in Sodium Hydroxide Solution Is Inconsistent with International Specifications
Hanayo Kodama1), Yoshinaga Tamura1), Ichiro Kamei2), Kyoko Sato3), Hiroshi Akiyama4)

1) Quality Assurance Department, Functional Additives Division, Performance Materials SBU, Asahi Kasei Corporation 2) Division of Forest Science, Department of Forest and Environmental Sciences, Faculty of Agriculture, University of Miyazaki 3) Division of Food Additives, National Institute of Health Sciences 4) Division of Foods, National Institute of Health Sciences
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