Bioavailability of a poorly water-soluble drug can be improved by preparing its aqueous nanosuspension in the presence of various stabilizers via wet milling and subsequently drying the suspension into nanocomposite microparticles or shortly nanocomposites. Unfortunately, drug nanoparticles aggregate during milling and drying, causing incomplete recovery and relatively slow dissolution from the nanocomposites. While various stabilizers/dispersants can be used to mitigate the extent of nanoparticle aggregation, excessive use of surfactants and sugars/sugar alcohols may be undesirable due to toxicity, relatively low drug loading, etc. In addition, due to differences in wetting and dissolution behavior, different types of polymeric stabilizers or different molecular weights of the same polymeric stabilizer can affect the drug release from the nanocomposites. The aim of this study is to (i) investigate the feasibility of preparing high drug-loaded, surfactant-sugar-free nanocomposites and (ii) explore the impact of various polymeric stabilizers on the wet-milled drug particle size and dissolution performance.