Development of Polycaprolactone/Poly(Vinyl Alcohol)/Clay Microparticles by Spray Drying

In this study, nanostructured microparticles was developed with polycaprolactone (PCL), poly(vinyl alcohol) (PVAL) and nanoparticles of the commercial sodium clay NT-25® by using the spray drying technique. The systems obtained were characte- rized by Nuclear Magnetic Resonance (NMR), Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Dynamic Laser Light Scattering (DLS) and Differential Scanning Calorimetry (DSC). The NMR 13C and FTIR techniques showed that both polymers were present in the mi- croparticles and the DSC analysis revealed a small variation in the glass transition temperature of the PCL. The XRD and SEM analyses showed that the microparticles produced were amorphous and had a concave morphology. The NT-25 nanoload reduced the microparticles’ size due to the multiple interactions formed in the hybrid nanocomposite material. Therefore, it was possible to develop microparticles by us- ing biodegradable and biocompatible polymers, with different polarities, allowing the incorporation of hydrophilic and hydrophobic materials and enabling the inclusion of otherwise incompatible materials in the same system.

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Development of Polycaprolactone/Poly(Vinyl Alcohol)/Clay Microparticles by Spray Drying
de B. Monteiro, M.S.de S., Rodrigues, C.L., Miguez, E. and Tavares, M.I.B. (2016) Development of Poly- caprolactone/Poly(Vinyl Alcohol)/Clay Mi- croparticles by Spray Drying. Materials Sci- ences and Applications, 7, 575-592. http://dx.doi.org/10.4236/msa.2016.710048
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