Formulation and In-Vitro Evaluation of Controlled  Porosity Osmotic Pump Release Tablets of Nifedipine

In this study, osmotically controlled drug delivery system of Nifedipine using different polymers were formulated. Nifedipine, is an anti-hypertensive drug. It acts as a calcium channel blockers. Unlike any other conventional dosage forms in osmotic system, the mechanism involved is osmosis. In the present studies, the release of the drug is porosity.A total of nine formulations were prepared by using the different polymers (Poly Ethylene oxide, HPMC K15 M and Ethyl cellulose) in different ratios in each formulation were formulated. The tablets were prepared by direct compression method using single station punching machine. The tablets were then dip coated using water soluble coating solvents (cellulose acetate pthalate, PEG, acetone and water). In-vitro studies of controlled release osmotic tablets of nifedipine was carried out.