The search for excipients to replace microcrystalline cellulose (MCC) in the production of pellets by extrusion-spheronization in cases of drug incompatibility or the lack of pellet matrix disintegration forms the basis of this study. A combination of к-carrageenan as a spheronization aid, chitosan as a diluent, and Carbopol® 974P as a binder in the production of pellets containing no MCC has been investigated using acetaminophen as a model drug.