Aim: The aim was to develop a novel excipient from Pleurotus tuber-regium (PT)-cornstarch (CS) mixture and evaluate its multifunctional characteristics in tablet formulation. Materials and Methods: Composites were generated from dephytochemicalized PT and CS combined at 1:1 to 4:1 ratios and pregelatinized in a hot water bath at 65°C ± 2°C for 5 min. The paste was dried, pulverized, and screened through 150-μm sieve. PT-CS physical mixtures were prepared and their characteristics / functionalities in tableting chloroquine were compared to those of composites and microcrystalline
cellulose (Avicel®).
Development and evaluation of Pleurotus tuber-regium-cornstarch composite as a direct compression multifunctional excipient
Okoye EI, Onyekweli AO. Development
and evaluation of Pleurotus tuber-regium-cornstarch composite
as a direct compression multifunctional excipient. Int J Pharma
Investig 2016;6:10-22.
and evaluation of Pleurotus tuber-regium-cornstarch composite
as a direct compression multifunctional excipient. Int J Pharma
Investig 2016;6:10-22.