Co-Processed κ-Carrageenan-Pectin as Pelletizing Aid for Immediate Release Pellets

This study investigates the extrusion-spheronization performance of some mixtures of co-processed κ-carrageenan and pectin (as excipient), and sodium starch glycolate (as superdisintegrant). Attention is focused with an objective to improve the mechanical stability and the dissolution rate of poorly-soluble domperidone (as a model drug). Initially co-processed κ-carrageenan- pectin excipient is prepared with different ratios of κ-carrageenan and pectin. Different marketed brands of κ-carrageenan (Gelcarin, Aquagel, and Eugel) were employed and dried by solvent evaporation method. Further characterization was carried out by SEM, XRD and FTIR analysis. Pellets were prepared using extrusion-spheronization technique. Pellets were evaluated for flow properties, particle size, sphericity, tensile strength, friability, disintegration time, and in-vitro drug release studies.

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