Drug–Excipient Interactions - Article March 2001

Although considered pharmacologically inert, excipients can initiate, propagate or participate in chemical or physical interactions with drug compounds, which may compromise the effectiveness of a medication. Excipients may also contain impurities or form degradation products that in turn cause decomposition of drug substances.This article explores some of these interactions and reactions,

and calls for a better understanding of excipient properties.

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Drug–Excipient Interactions
Patrick Crowley is a Vice President in Pharmaceutical Development
at GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
Dr Luigi G Martini Manager, Stategic Technologies. Pharmaceutical Development, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, CM19 5AW, UK.
Article Reprinted from the Pharmaceutical Technology Europe
©March 2001 issue of:
Article Reprint Number: 0582
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