22. November 2015

    Quasi emulsion spherical crystallization technique based environmentally responsive Tulsion® (pH dependent) microspheres for colon specific delivery

    pH-dependent sustained-release Tulsion® microspheres bearing clarithromycin were prepared using quasi-emulsion solvent diffusion method with thermocoat L 30 D 55 as a release retardant. Both, clarithromycin and thermocoat L 30 D 55, were found to be non-hemolytic during in vitro toxicity assay against human red blood cells. 

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    Tags: excipient, Acid, solvent, spherical, technique, method, clarithromycin, microspheres, Sustained-release, Crystallization, diffusion, copolymer, L, nov2015, Quasi-emulsion, Tulsion®, thermocoat, 30, D, 55, Methacrylic, type-C