Highlights
- Development of a new biorelevant dissolution method for orodispersible films, considering mechanical force, saliva flow, volume and composition.
- Comparison of different conventional methods and the new biorelevant dissolution method regarding their consideration of in vivo conditions.
- Feasibility and problems of different dissolution setups for orodispersible films.
- Conventional dissolution setups show faster concentration onset compared to the new developed biorelevant setup.
- The simulated saliva flow has a higher impact on the dissolution of orodispersible films compared to the mechanical force.