Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders - Abstract

This study investigates the effects of a variety of coating materials on the flowability and dissolution of dry-coated cohesive ibuprofen powders, with the ultimate aim to use these in oral dosage forms. A mechanofusion approach was employed to apply a 1% (w/w) dry coating onto ibuprofen powder with coating materials including magnesium stearate (MgSt), l-leucine, sodium stearyl fumarate (SSF) and silica-R972.

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