Highlights
- Nanoparticles of chitosan-sodium tripolyphosphate (CS-TPP) are formed in the dilute and semi dilute regime
- The degree of coil space-occupancy (product of concentration and intrinsic viscosity) is a fundamental parameter to consider in the preparation of CS-TPP nanoparticles
- In general, the size and zeta potential of the nanoparticles are determined by the the degree of acetylation (DA) of CS
- Two type of behaviors are recognized at low (DA<30%) or high (DA>%)
- The molar ratio of glucosamine/TPP accounts for the DA of CS and also determine the physical properties of the nanoparticles