The effect of mechanical grinding on the formation, crystalline changes and dissolution behaviour of the inclusion complex of telmisartan and β-cyclodextrins - 

Highlights

•The inclusion ratio was established by phase solubility study and Job Plot.

•The complexes were characterized by DSC, XRPD, FTIR and SEM.

•The complexes' configuration was proposed by Computer Molecular Modeling.

•Complexes achieved dissolution rates comparable with the marketed reference medicine.

•Complexes showed faster pharmacological effect than the free drug during in vivo studies

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