By: Ben Nelson, PhD, and Chris Wilcox
Trehalose is a non-reducing disaccharide consisting of two glucose molecules linked by an α,α–1,1 glycosidic bond. In the pharmaceutical industry, products that benefit from the stabilizing
effects of trehalose include, but are not limited to: monoclonal antibodies (mAbs), antibody drug conjugates (ADCs), fusion proteins, peptides, stem cells, and vaccines. Table 1 is a brief list
of drugs that include trehalose as a component of their formulations.