Head-To-Head Comparison of Different Solubility-Enabling Formulations of Etoposide and Their Consequent Solubility–Permeability Interplay

The purpose of this study was to conduct a head-to-head comparison of different solubility-enabling formulations, and their consequent solubility–permeability interplay. The low-solubility anticancer drug etoposide was formulated in several strengths of four solubility-enabling formulations: hydroxypropyl-β-cyclodextrin, the cosolvent polyethylene glycol 400 (PEG-400), the surfactant sodium lauryl sulfate, and an amorphous solid dispersion formulation...

http://onlinelibrary.wiley.com/doi/10.1002/jps.24496/abstract;jsessionid=60BEE674D85CC2EC5965E867A436BA96.f04t01?deniedAccessCustomisedMessage=&userIsAuthenticated=false