07. May 2015

    Stages in spheronisation: Evolution of pellet size and shape during spheronisation of microcrystalline cellulose-based paste extrudates

    •Tests with coloured pastes show that fines do not attach preferentially at pellet waist.

    •New ‘dumb-bellity’ measure to quantify the formation of dumb-bells

    •Spheronisation time increases with mass of charge until overmassing occurs.

    •Tests with calcium carbonate as model API exhibit the same behaviour.

    http://www.sciencedirect.com/science/article/pii/S003259101400864X

    Tags: excpient, microcrystalline, cellulose, extrusion, may2015, breakage, spheronisation, Rounding, shape