22. April 2015

    The effect of excipients on the stability and phase transition rate of xylazine hydrochloride and zopiclone.

    Highlights

    • IR spectroscopy showed absence of chemical interaction between excipients and drug.

    • In thermal analysis physical interaction between excipients and drug was identified.

    • Some excipients promoted but some reduced stability of the API unstable polymorph.

    • Phase transition rate of API depended on the type and the amount of excipient added.

    http://www.sciencedirect.com/science/article/pii/S0731708514006384

    Tags: excipient, apr2015, stability, phase, transition, kinetics, polymorphs, thermal, properties